nuclear throne large chest

Stronger version of the Machinegun. Has less reload time than the regular Assault Rifle. It won't fire automatically with 0 explosive ammo. i typically just skip one, then wait, unless i have good questions and am set on ammo.not sure what's most efficient (though I suspect it's skipping just the one), but im pretty sure it's always worth it to skip the one each time.from the wiki: "Contains 3 weapons and a large amount of ammo for those weapons (2 Mini Ammo Chest pickups for each weapon).If you leave a regular Weapon Chest unopened, there's a 25% chance for a Large Weapon Chest to spawn on the next level. Stacking the swing projectiles with the Eagle Eyes Your character starts with the standard 96 Bullet type ammo. The big projectile doesn't create a Plasma Explosion but it will destroy walls before splitting. Deals less damage on impact than the regular Crossbow. Accurate, but has the lowest rate of fire of all automatic bullet weapons. It will deal less damage as it gets smaller. You are up 1 weapon (3 - 1 you skipped - 1 for the large chest's level). It won't fire automatically with 0 explosive ammo. Doesn't hurt you when fired directly into a wall. Uses a lot of ammo. Fires a spread of five splinters. Then, I skip the chest right after each large chest to get the 25% chance again, unless I really have crappy weapons and Lil' Fucker is right around the corner.For me I always save up to and open a big chest at 3-3 and 5-2/3, I have a laser pistol on fish (My Main) and ammo usually isnt a problemedit: this comment's mathematical basis is now invalid, see belowIf you skip one red chest you will get a large weapon eventually. Fires an even bigger plasma blast than the Plasma Cannon. A bazooka that shoots five rockets in a fixed spread. Fires 3 green enemy-like projectiles in a small spread. Shoots faster than the Machinegun, but is considerably less accurate.

Doesn't have a laser sight but still increases your view distance like a Crossbow.

i seriously doubt going from 25-50% chance is worth it unless you're full up or just lazy (though that would be where math might come in), but it seems like going from 0-25% is obviously worth it. that chance goes up the more you skip i think. The lightning can then hit the enemy for 7 damage; but if the lightning does not touch the enemy, the slash can then hit a second time dealing a further 14 damage. As with all shell weapons, it deals more damage up close. Missing enemies with it can deal more damage than just direct hits. Fires a slow moving, spinning projectile that spews out two streams of red fire burning anything in its path. Uses high amount of Energy type ammo each shot. Skipping a Large Weapons Chest adds the same 25% chance as skipping a regular one.

High damage per second, very effective against bosses. The pellets deal more damage to targets directly hit with the ball or targets that are close when it splits, no matter how far the ball traveled.

Shoots out one more pellet than the regular Shotgun. On top of bringing the Laser Cannon's lasers to the potential damage of 2-12, the Laser Brain mutation also adds 2 more lasers to the burst for a total of 7.

Starting with a Golden Frog Pistol replaces your character with the Fires golden discs that travel faster than regular ones. Hitting it with a Screwdriver or a Jackhammer splits it into mini grenades and causes them to explode immediately after. Technically it appears on the target, but it can be reflected. Shoots a bolt that deals massive damage to a single target. The big plasma blasts act the same as Plasma Cannon's projectile and will split into 10 smaller plasma projectiles. Has a faster rate of fire than the regular Bazooka. If you skip one red chest you will get a large weapon eventually. Creates three crescent swing visuals in an arc dealing damage over a wide area.

Can still be used if you run out of explosive ammo but it will deal 1 damage to your character each shot. Very slow; high damage.

This weapon always does 16 damage each swing. You are up 1 weapon (3 - 1 you skipped - 1 for the large chest's …

Unlike the Blood Launcher's grenade, this projectile will destroy walls on impact. Blood Explosions themselves won't destroy walls. Creates one big green explosion.

There is a slight delay before the cloud spawns, giving the player a chance to evade it. The main projectile and the 4 big projectiles don't create a Plasma Explosion but they will destroy walls before splitting.