It is essential that blend refrigerants be charged by removing only liquid from the cylinder. It has a very low loss in capacity (0 – 5%) relative to R-22 and is less expensive than many other R-22 replacement refrigerants.If a system has R22 in it already you cannot use a replacement refrigerant to simply add to the R22. Refrigerant R407C has a good energy efficiency ratio as well as a low compression pressure and In case of replacement the R22 must always be switched to Due to its relatively high GWP value, however, R407C will be replaced with refrigerants with a lower GWP value.R407C is a commonly used refrigerant mixture for air conditioning systems, water cooling equipment and, for example, in the high and medium temperature cooling solutions of ships. It is found after the careful observation that R22 performs somewhat better than R407C in many aspects i.e. 1. It is a zeotropic blend of difluoromethane (R-32), pentafluoroethane (R-125), and 1,1,1,2-tetrafluoroethane (R-134a).